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The gene MC4R is the most commonly mutated gene in monogenic obesity, and variants of the FTO gene are closely associated with an increased body mass index and frequent obesity in the general population ( 2 ), gene mutations that influence these signaling pathways are relatively common ( The impact of genetic mutations on the effectiveness of weight loss medications has been demonstrated, with variations in genes influencing the response and outcomes of treatment

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Singh, M., Deo, S

Improvement of irritable bowel syndrome with glucagon like peptide-1 receptor agonists:a systematic review and meta-analysis