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Semaglutide was associated with reduced alcohol consumption and blood alcohol levels during the laboratory drinking task Participants receiving semaglutide drank less (bar graph below) and achieved lower blood alcohol levels during the end of treatment alcohol self-administration paradigm
For further confirmation, the expressions of endothelial markers (VE-cadherin and ZO-1) and mesenchymal markers (-SMA and vimentin) in HUVECs were detected by West blotting
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