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tb was determined within in vitro granulomas of infected-PBMCs from T2DM subjects that were either untreated (control), treated in vitro with PZA (one-time addition at 5 g/ml) or with INH (one-time addition at 0.0125 g/ml)

This may include: Assessment for fecal impaction (digital rectal exam or imaging) Evaluation for other causes of constipation (hypothyroidism, medication interactions, structural issues) Discussion of dose reduction or treatment alternatives Prescription motility agents (prucalopride, linaclotide) Referral to gastroenterology for refractory cases Foods and supplements that worsen GLP-1 constipation Constipating foods to limit or avoid: Processed foods low in fiber

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Hasan et al., 2023)