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Furthermore, GLP-1 RAs exhibit anti-inflammatory effects, lowering circulating levels of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1), and IL-6, while promoting anti-inflammatory mediator production [26]
PCA analysis results revealed that under different dietary backgrounds, the ND group was clearly separated from the other groups with no intersection
Therapeutically, the integration of RAAS inhibitors, SGLT2 inhibitors, and non-steroidal mineralocorticoid receptor antagonists has transformed DKD management from glucose control to organ protection (Mimura et al., 2025
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