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The gastrointestinal effects result from tirzepatide's action on GLP-1 receptors, which slow gastric emptying and affect gut motility

Target patient populations include people who have shown inadequate response to traditional treatment based on the use of GLP-1 receptor agonists monotherapy, people that require stronger metabolic treatments for the purpose of reversing the disease or prevention of related cardiovascular diseases, and people looking for alternatives to bariatric surgery for overcoming obesity and related diseases such as sleep apnea and non-alcoholic steatohepatitis

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They activate the same pituitary GHRH receptor, so using both simultaneously doesnt add much beyond using either one at a higher dose