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Wegovy and Zepbound, weekly injections used for weight loss
found that highly metastatic CRC cells primarily rely on glutamine-driven TCA cycle activity to sustain energy production, whereas low-metastatic cells tend to depend more on glycolysis [94]
Rarely, allergic reactions (including anaphylaxis) have been reported, particularly in individuals with occupational exposure to ispaghula dust
This remains an important pharmacological consideration as retatrutide progresses through clinical development, and mechanistic conclusions should be regarded as provisional pending further evidence
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