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Oral GLP-1 medications may be a reasonable option for: Patients early in their weight loss journey Patients with mild to moderate weight loss goals Patients who strongly prefer to avoid injections They may be less ideal for: Patients who have had bariatric surgery Patients needing significant weight loss Patients who have not responded to oral medications in the past The decision is not just about preference

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MTHFR and its activity While MTHFR gene codes for different variants, the most common form of MTHFR in human is a 656 amino acids protein

PMID 21428697