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Authors perspective and future directions Current evidence supports SGLT2 inhibitors as a core component of contemporary heart failure management because of their consistent reductions in HF hospitalization and cardiovascular death across a broad range of patient populations [8,9,10,11,12,13, 45, 49]

Seyfried TN, Sanderson TM, El-Abbadi MM, McGowan R, Mukherjee P

The cardiovascular benefits observed with these medications include: Reduction in non-fatal myocardial infarction and stroke Decreased cardiovascular mortality in high-risk populations (demonstrated with liraglutide) Improvements in blood pressure and lipid profiles Weight reduction , which independently lowers cardiovascular risk It is important to distinguish between arterial thrombotic events (such as heart attacks and strokes, which some GLP-1 agonists help prevent) and venous thromboembolism (DVT and PE)

For example, metformin, a well-studied HDT agent, not only limits excessive inflammation and tissue damage by modulating immune responses but also promotes autophagy through mTOR inhibition, thereby enhancing the clearance of M