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Inclusion criteria: all participants must: be 65 years of age be attending a primary healthcare centre for consultation on some medical matter provide their informed consent to be included have a serum B12 concentration of 200 pg/ml at 4 months in over 70% of patients
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Cognitive improvements were evident at doses of 200, 400, and 800 mg/kg/day, as confirmed by passive avoidance and Y-maze tests (Lim et al., 2018)
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