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Phase 2 documented a clear dose-response: 9.1% at 2.4 mg versus 10.8% at 4.5 mg at 26 weeks (Lau et al., 2021)
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Analysis of interleukin-1 (IL-1) and interleukin-8 (IL-8) expression and release in in vitro reconstructed human epidermis for the prediction of in vivo skin irritation and/or sensitization
