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Among them, small-molecule lysosome-targeting degraders, such as autophagy-mediated PD-L1 degraders [93], and certain lysosomal pH modulators, including hydroxychloroquine-based regimens that have been explored in clinical settings [66], appear to be comparatively closer to clinical application, in part due to their more established pharmacokinetic profiles and, in some cases, oral bioavailability
Mowatt-Larssen 2010
For IGF-1 LR3 specifically, the IGF-1 LR3 dosage calculator walks through the same math
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