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The NIH's general framework for peptide pharmacokinetics confirms that hepatic contribution to small peptide clearance varies widely, from negligible to dominant, depending on lipophilicity and plasma protein binding
Thymosin beta-4 represents the endogenous parent peptide from which TB-500 derived fragments originate and is widely studied for its actin-binding behavior and role in cellular migration signaling
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& Wulf, H
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