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7 Pharmacists should be diligent in staying up to date with emerging benefits of GLP-1 RAs, especially in new indications such as PD, and follow releases of new clinical data that more confidently highlight the role of GLP-1 RAs in PD

PMID 18221116

Key considerations when switching: Allow a washout period based on tirzepatide half-life Start retatrutide at the standard 1mg initiation dose regardless of previous tirzepatide dose Expect renewed GI side effects as the glucagon receptor is a new stimulus Monitor heart rate more carefully during the initial escalation period When tirzepatide is the better choice Tirzepatide remains the superior option in several specific situations

Their body needs more liquids