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We found consistent evidence for the presence of NETs in human and murine gallstones and describe an immune-mediated process requiring activation of the innate immune system for the formation and growth of gallstones, the investigators wrote

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The rare individual who might consider this combination needs exceptional GI tolerance proven on prior GLP-1s, physician supervision with frequent monitoring, ability to afford $15,000-30,000 annually, understanding they're experimenting on themselves, and willingness to stop immediately if severe side effects emerge

Mounjaro is injected once weekly using a pre-filled pen