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People struggling with addiction have fewer dopamine receptors in part of the brains reward pathway, so the same reward tends to bring less pleasure, fueling the addiction cycle
GLP-1 medications are FDA-approved for certain medical conditions, and providers may also prescribe some of them off-label based on clinical judgment
The FDA maintains the boxed warning because proving a negative, proving that something definitively does NOT cause cancer, requires decades of surveillance data
The EMA classifies it as safe, and adverse effects reported in clinical trials are generally mild and transient
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