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The GLP-1 receptor agonists are generally recommended as a second or third-line option as add-on to metformin therapy in patients with T2DM who do not have ASCVD/indicators of high-risk for ASCVD, HF, or CKD and who need to minimize hypoglycemia and/or promote weight loss

Note on Phase 3 sources: Topline results for TRIUMPH-4 (announced December 2025) and TRANSCEND-T2D-1 (announced March 2026) are sourced from Eli Lillys primary disclosures

Beyond gastrointestinal effects, the FDA prescribing information for tirzepatide notes additional adverse reactions that occurred during clinical development

When to Seek Medical Advice About Stomach Pain Whilst mild to moderate stomach pain is a recognised side effect of Ozempic, certain symptoms warrant prompt medical evaluation to exclude serious complications or alternative diagnoses