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Too much overwhelms protective mechanisms
The group of Schulzke an co-workers showed a disturbance of the barrier function which was accompanied by a down-regulation of claudin-1, 3, 5, 7 and 8, and an up-regulation of claudin-2, a pore-forming claudin, together with a re-distribution of claudin-5 and 8 off the tight junction domain of the enterocytes in intestinal biopsies of patients with CD [23]
The choice between injections and supplements depends on multiple factors, including the severity of deficiency, underlying health conditions, and individual absorption capabilities
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