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The authors failed to provide a satisfactory explanation and as a result, the conclusions of the article have been deemed unreliable. A Frontiers spokesperson did not elaborate when The Transmitter asked for more details about the specific issues with the paper

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There are a couple of other scenarios in which acetaminophen is more likely to cause liver damage: Alcohol Use Disorder: Normally, alcohol is metabolized using the alcohol dehydrogenase enzymes, but in cases of chronic overconsumption or binge drinking, the CYP2E1 enzyme is upregulated to metabolize the extra alcohol

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