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This protein is made by the similar parietal cells that are damaged in autoimmune gastritis
Animal studies show it accelerates healing of intestinal wounds, fistulas, and NSAID-related gut damage, with early human trial data showing a strong safety profile
NNMT is a cytosolic S-adenosyl-L-methionine-dependent methyltransferase that converts nicotinamide to 1-methylnicotinamide, spending SAM and diverting nicotinamide away from the NAD+ salvage pathway
Receptor-mediated sorting of soluble vacuolar proteins ends at the trans-Golgi network/early endosome
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