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In the original mouse work it was described as well-tolerated, but that is the limit of the in-vivo safety evidence, and it is mouse-only

Glucagon normally signals the liver to release stored glucose, so suppressing it after meals helps prevent unnecessary elevations in blood sugar particularly useful in people with insulin resistance or type 2 diabetes

The selected compounds for this assay were incubated at different concentrations (6 mg/mL, 3.0 mg/mL, 1.5 mg/mL, and 0.75 mg/mL of the samples, and 0.06 mg/mL, 0.03 mg/mL, 0.015 mg/mL and 0.0075 mg/mL of Alendronate) and incubated with 50 L of human erythrocytes resuspended in 950 L of saline solution

While the calculator is not intended for clinical or personal use, it demonstrates how doses in clinical trials translate into measurable laboratory quantities