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Activate Sirtuin 1 Sirtuin 1 (SIRT1) is an nicotinamide adenine dinucleotide (NAD +) dependent class III histone deacetylase (HDAC) that belongs to the sirtuin family of proteins
Future clinical trials should refine the investigation of the direct analgesic properties of GLP-1RAs in osteoarthritis, differentiating these from the benefits linked to weight reduction, to better evaluate their clinical utility in managing osteoarthritis-related pain
Summary: Mounjaro patients should prioritise a balanced diet, with supplements considered only for confirmed deficiencies or insufficient dietary intake, focusing on vitamin B12, vitamin D, and calcium when clinically indicated
Ratajczak, J
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