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Cultures A2 (with matrix) and A3 (without matrix) were incubated in anaerobiosis at 37 C for 72 h
A 2025 systematic review and meta-analysis in JAMA Psychiatry found no overall increase in psychiatric side effects, including depression, with GLP-1 medications
Additional studies have consistently shown that GLP-1 agonists improve systolic and diastolic blood pressure readings, particularly in patients who achieve significant weight loss
Although most current studies are confounded by metabolic comorbidities, recent findings by Nicolau et al 5 begin to address this gap by evaluating the effects of GLP-1 RAs in metabolically healthy patients, providing preliminary support for a direct immunologic mechanism
