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Recent studies have suggested that polyphenols may have the ability to regulate epigenetic processes, which holds significant clinical and therapeutic implications [141]
Kildegaard et al
Another study demonstrated that active and passive smoking were linked to more advanced histological stage and higher mortality in PBC patients
While preparing this manuscript for submission, a study based exclusively in in vitro assays was published showing that the addition of 25 M BSO or the use of tools to delete GCLC inhibits the growth of Burkitt lymphoma cell lines under 2D culture conditions [42], seemingly suggesting a comparable susceptibility to glutathione starvation between TICs and differentiated tumor cells
