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These combined effects create a powerful metabolic shift that addresses weight gain at multiple biological levels rather than simply suppressing appetite through stimulation
Semaglutide slows down the movement of food from the stomach to your small intestine, causing food to stay in your stomach for a longer time (delayed gastric emptying), which can cause feelings of fullness and discomfort
And orforglipron comes with an added advantage of having no dietary restrictions compared to other oral GLP-1s
Examples of the VRS are shown in Fig
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