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In 3,533 adults with type 2 diabetes and chronic kidney disease, semaglutide 1.0 mg reduced the primary composite kidney outcome by 24%
This aligns with the fact that overexpression of PPAR coactivator 1-alpha (PGC-1), a regulator of mitochondrial biogenesis, increases the generation of CD8 central memory T cells and, in general, improves murine immune responses following infection, immunization, and in the generation of antitumor immunity (131)
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