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There was no plateau, and in fact it appears longer term trials will probably easily clear 20% weight loss, especially if metformin and/or SGLT2i medications are added on as these can both add another 2-3% extra weight loss when combined with a GLP-1 medication

Discontinuation of Tirzepatide and Semaglutide Prior to Gastric Sleeve Surgery: [PMID: 40163291] Laboratory literature summary: Discontinuation of Tirzepatide and Semaglutide Prior to Gastric Sleeve Surgery: laboratory Considerations and Guidelines

In a small group with T2D, SAR425899 improved fasting glucose and glucose tolerance after a mixed meal ( Several other multi-agonists capable of co-agonism of the GLP-1 and glucagon receptors are currently in development including BI 456906 (Boehringer Ingelheim), LY3305677 (Lilly) LY4347943 (Lilly), JNJ-54729518 (J&J), HM15211 (Hanmi), NNC9204-1706 (Novo), Alt-801 (Altimmune) and G3215 (Imperial College/Zihipp Ltd.) see Table 1

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