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The following timeframes are supported by clinical trial data and prescribing information: Nausea: Most commonly peaks in the first one to two weeks at each dose level, then improves significantly over weeks three to four

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*Correspondence: Tao Wu, [email protected] These authors have contributed equally to this work This article was submitted to Reproduction, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

This mechanism reduces the risk of hypoglycaemia compared to some other diabetes medications