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14 Some research suggests that certain types of fiber (fermentable fibers found in oats, beans, and some fruits/vegetables) can be broken down by gut bacteria into short-chain fatty acids, which may naturally stimulate the body's own GLP-1 production
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The alanine at position 8, the residue immediately adjacent to the DPP-4 cleavage bond, is replaced by alpha-aminoisobutyric acid (Aib), a non-canonical, doubly methylated amino acid whose steric bulk blocks protease access [1]
In terms of pharmacological effects, it stimulates the release of growth hormone (GH) from the anterior pituitary gland by activating the growth hormone releasing peptide receptor
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