Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (which can be caused by ingestion of corrosives, extensive tumors, and conditions associated with gastric atrophy, such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy) Structural lesions leading to vitamin B 12 deficiency, including regional ileitis, ileal reactions, and malignancies Competition for vitamin B 12 by intestinal parasites or bacteria
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Board-certified reproductive endocrinologist and infertility specialist Armando Hernandez-Rey, MD considers the following key factors: Body mass index (BMI) Insulin sensitivity Metabolic markers, such as glucose and lipid levels Overall reproductive goals A good candidate is typically someone with obesity or overweight who has not responded well to lifestyle changes alone and shows signs of metabolic dysfunction [such as weight gain and insulin resistance] commonly seen in PCOS, Dr
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