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This protective effect was primarily due to the inhibition of the intestinal farnesoid X receptor (FXR)
EVK, H., et al., Exposure to continuous darkness ameliorates gastric and colonic inflammation in the rat: Both receptor and non-receptor-mediated processes
The mechanisms through which estrogen prevents bone loss are uncertain
Targeting the MIF pathway could therefore represent a promising therapeutic strategy, converting immunosuppressive MDSCs into pro-inflammatory, antitumor DC-like cells, and thereby reinvigorating antitumor immune responses in late-stage melanoma patients
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