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Description

Shcherban, O., & Dzhus, I

Intragastric administration of the bitter tastant quinine lowers the glycemic response to a nutrient drink without slowing gastric emptying in healthy men

Bioscience Reports

Some of these effects are in fact analogous to those previously observed by reducing beta cell/islet cholesterol with simvastatin: for example, both manipulations led to a reduction in GLP-1R plasma membrane lateral diffusion under vehicle conditions, as well as acute increases in GLP-1R-induced cAMP and islet insulin secretion responses