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Second: the short plasma half-life (~30 min) was insufficient, by the time the fragment circulating in the blood was supposed to act, it had already been metabolized
Unsurprisingly, serum IL-10 level is remarkably lower in RA patients ( As anti-inflammatory factors, the injection of L-4, IL-10, IL-13, TGF-, or their agonist can play therapeutic roles
given subcutaneously the apparent half-life is substantially longer, in the region of a day
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