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48 We only reported HR estimates from analyses that passed all study diagnostics, specifically 25% patients having preference scores between 0.3 and 0.7 in both cohorts (25% empirical equipoise), maximum absolute standardized mean difference on patient covariates 0.15 after PS adjustment, MDRR 4, and empirical average systematic error evaluated from negative control outcome estimates 0.25

Clinical trials in centenarians demonstrate that L-Carnitine treatment (2 g/day for 6 months) significantly reduces severity of physical and mental fatigue, improves muscle mass while reducing total fat mass, and enhances walking capacity and cognitive functions

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