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For prescription fills exceeding a 30 day supply, we assumed supply extended across subsequent months (e.g., a 60-day fill was counted as two months of supply)

GLP-1 Research Comparison: Semaglutide vs Tirzepatide vs Retatrutide Mechanism, receptor targets, and research focus areas for the three most-studied incretin receptor compounds in metabolic research

"There's some data to suggest that a dose tapering strategy, so where you minimize or lower the doses over time might prevent weight regain."

BRP stands for BRINP2-related peptide, a naturally occurring molecule derived from the BRINP2 protein in the human body