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This gradual escalation continues until the desired therapeutic effect is achieved or the maximum tolerated dose is reached

Cleveland Clinic 2025 Assessed and Endorsed by the MedReport Medical Review Board

Pulungan AB, Afifa IT, Annisa D

69,70 Notably, findings from pharmacovigilance databases and real-world cohorts have been inconsistent, with some reports suggesting an association with specific agents, such as semaglutide, while others have not observed such relationships