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This controlled mitochondrial handling of Ca 2+ supports metabolic output and enables soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) and their proteins (syntaxin-2/11, SNAP-23, VAMP-7/8) mediated graded -granule exocytosis necessary for platelet plug stabilization without producing excess thrombus (Pokrovskaya et al., 2018)
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Is compounded semaglutide the same as Ozempic or Wegovy
Indications: Huntington's Chorea (a hyperkinetic movement disorder) A drug of first choice for this condition Side Effects: Sedation Depression (suicidal tendencies) Parkinsonism symptoms Lacks the hypotensive & GI side effects of reserpine due to its selectivity for central VMAT2 Pharmacokinetics: * undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 active metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), with eventual renal elimination of metabolites the -HTBZ and -HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent prodrug Readily crosses the blood brain barrier & depletes cerebral monoamine stores
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