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Ideal candidates include individuals with uneven skin tone, chronic sun-related pigmentation, melasma, or dull complexion driven by environmental exposure concerns that are particularly prevalent among patients from Andheri, Juhu, Versova, and Lokhandwala due to Mumbais year-round UV intensity

In this paradigm, the concentration and identity of circulating fragments encode the state of the tissue: a matrix under active remodeling produces a different fragment profile than a quiescent one

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