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when shorts are broken up, desensitization does not occur

( f ) Acetyl-CoA abundance was assessed in cells transduced with shRNA targeting TMLHE with or without supplementation with the indicated doses of acetate (n = 8 technical replicates representative from 2 independent experiments)

Several studies have reported that antioxidants can downregulate or inhibit cytochrome P450 enzymes, particularly CYP2E1, which is pivotal in APAP bioactivation (Carrasco et al