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This positive feedback loop promotes Wnt target gene expression, autophagy activation, drug efflux, and gemcitabine resistance
blend, paired with Vitamin B12
Systemic copper toxicity (hypercupremia) requires ingesting or absorbing significant amounts of copper over time
This observation led us to propose that the primary GtmA function is to negatively regulate gliotoxin biosynthesis, post-DTG formation- although gtmA orthologs may be protective against gliotoxin in non-gliotoxin producing fungal species (e.g., Aspergillus niger ) (Manzanares-Miralles et al., 2016)
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