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Small-molecule activators of ATF6 are being developed to enhance ER folding capacity, stimulate ERAD, and reduce ER stress, with potential benefits in heart failure and ischemic cardiomyopathy
Supports mitochondrial health and cellular energy by promoting efficient energy metabolism and antioxidant activity
This cascade of mitochondrial damage, along with the impaired ability of mitochondria to regulate calcium homeostasis and bioenergetics, leads to further neuronal injury and death [157]
In the ischemia/reperfusion-induced fibrosis C57BL/6J mouse model, transcriptomic and metabolomic analyses showed that dapagliflozin treatment mitigated accumulation of tricarboxylic acid (TCA) circulating metabolites and up-regulation of inflammation in fibrotic renal cortical tissue
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