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GI-symptoms were divided in five syndromes: abdominal pain, constipation, diarrhea, gastro esophageal reflux disease and indigestion

Frequency varies depending on individual wellness routines and goals

Given these reported outcomes regarding weight reduction and appetite control in obesity associated with the MC4R pathway, it is plausible to hypothesize that setmelanotide may exert similar effects in MC4R-deficient obesity

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