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More specifically, research shows small peptides under 16 kilodaltons (kDa) primarily leave the injection site through diffusion into blood capillaries, while larger proteins are predominantly absorbed via the lymphatic system

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At the 12mg dose, retatrutide reduced HbA1c by 2.2 percentage points over 36 weeks while simultaneously producing 16.9% body weight reduction a dual glycemic and metabolic benefit not observed at comparable levels with single or dual agonists

This personalization accounts for the relationship between body mass and peptide distribution