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Notably, subjects carrying MC1R variant alleles who typically tan poorly and are at higher skin cancer risk showed a greater melanin response than those with wild-type MC1R (Fitzgerald et al., 2006)

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Importantly, hyperactivation of STING1 is also a bridge between autophagy and ferroptosis that STING1 directly promotes ferroptosis by overactivating autophagy in the context of DNA damage [260]

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