glutathione causes diarrhea Frontiers How Long Can You Live

doi: 10.1038/s41588-018-0099-7 26

Glutathione exerts its hypopigmentary effect by several mechanisms namely direct (by binding with the copper-containing active sites) and indirect (via antioxidant effect leading to exhaustion of free radicals and peroxides) inhibition of tyrosinase enzyme (the key enzyme for melanogenesis).[] It also switches the production of eumelanin to pheomelanin by the formation of sulfhydryl-dopa conjugates.[] Additionally glutathione has been shown to scavenge UV radiation-induced reactive oxygen species generated in epidermal cells.[] Its antioxidative action also helps to lighten melasma, as several studies have confirmed the role of oxidative stress in melasma.[] Glutathione may be used orally (2040 mg/kg/day in two divided doses) or intravenously (6001200 mg)

Treatment with TCP, a specific inhibitor of LSD1, reduced the severity of IR-induced AKI by alleviating oxidative stress and ferroptosis

Possible side effects include minor pain at the injection site