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The American journal of psychiatry , 179 (9), 611627
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To our knowledge this is the first case where a pericentral damage pattern of hepatotoxicity mediated by other factors than cytochrome P450 was observed
Coskuns research contributions span the entire development arc of GLP3 : Discovery and initial characterization of GLP3 s triple-receptor agonist properties and pharmacological profile Preclinical studies establishing proof-of-mechanism in mouse models and in vitro receptor systems Design and medical oversight of phase 1b and phase 2 clinical trials in type 2 diabetes and obesity Investigation of GLP3 s effects on gastric emptying and mechanistic studies of weight loss Contribution to over 168 peer-reviewed publications in metabolic disease research with citation impact exceeding 8,700 citations His work extends beyond GLP3 to include fundamental contributions to the development of GLP2 and advancement of incretin-based therapeutics more broadly
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