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Molecular Therapy, 30 (2), 745762
Do not wait for routine labs Severe headaches, vision changes, fainting, chest pain, rapid swelling, or neurologic symptoms need medical review
Second-generation compounds like semaglutide improved on pharmacokinetic profiles, enabling once-weekly dosing and stronger clinical efficacy
2014 follow-up study was retracted in 2025, which means the foundational evidence base has significant integrity concerns that should be weighed carefully
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