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Research has shown that antioxidant interventions, including vitamin E, deferoxamine (DFO), or Fer-1, can alleviate ferroptosis in T cells lacking GPX4 ( Figure 2 ) (114)

Intracellular lipid peroxide (LPO) detection To detect the intracellular LPO content, 143B cells were incubated with PBS, Ru(II)-OH, NP2, and NP4 (Ru 10 M) for 6 h

Consistently, as evident from increased PSD95- and MAP2-positive puncta, we also observed an increase in the colocalization of postsynaptic PSD95 and neuronal marker MAP2 in the hippocampi of Hex-fed 5XFAD mice as compared with that in vehicle-fed 5XFAD mice (Figure 5, C and E, and Supplemental Figure 2B)

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