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The key regulatory genes of ferroptosis, such as SLC7A11, GPX4, and voltage-dependent anion-selective channels (VDACs) [1,2,3], can be regulated by a series of deubiquitinases, including ubiquitin-specific protease (USP) 11 [93], USP14 [94], and OTU domain-containing ubiquitin aldehyde-binding protein 1 [95], as well as ubiquitinases such as neural precursor cell expressed developmentally downregulated protein 4 (NEDD4) [96], NEDD4 ligase [17], and so on

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During epididymis transport, spermatozoa are vulnerable to intracellular and extracellular ROS attacks and rely on antioxidant scavengers synthesized by the epididymis for protection