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These factors contribute to inconsistent results that often temper the early promise seen in preclinical studies
they are not a tolerability forecast
Two symbols (**, ##, or $$) denote significant difference below 0.005, three symbols (***, ###, or $$$) denote significant below 0.0001
These comparisons mix a single agent versus a combination, which makes riskbenefit decisions more complex and should be handled by a clinician
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