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Puopolo is fantastic
The practical message is that a biologically plausible mechanism does not make something clinically effective, and absence of reported harm is not evidence of safety
Sleep-Linked Endocrine Rhythms and Neuroendocrine Timing A more specialized application concerns neuroendocrine timing and the relationship between growth hormone secretion and sleep architecture
However, their ability to dramatically improve metabolic health markers (insulin sensitivity, visceral fat, inflammation) addresses major drivers of biological aging
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